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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ecf596ecc2dd346fcda055436a5438892e94cf5160bad6022dd1f74881b2aa2b' 
  AND token = '4lRPZUW3mJMIEX/N53ytC+S9LWh85XhdgZkvZaB70Tw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}