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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd52226ee4f9bc3046aefc1e3671e090998d2f4dfdaf0f869f04320a825f3866e' 
  AND token = 'Rsxywkfsc6AoNIUZxTm+gWWUreyyFYax66XRvHh2klE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}