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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22dab4264d0383c01a18b00764476c5a8897ffb1a2e4cac322b47f57f7217c2b' 
  AND token = 'OLKy6XpPJbLXfGLFgqD7+wx/M3/aYaxkkSWHCYfkFxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}