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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0580dd7ed0dd2fec6337f1169f771abf194713b2da75a242e9e708de74f3a65d' 
  AND token = 'R5poWw6K7OnhcqYOVkfLLhyiRDZbfKnaR73REREHmsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}