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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21aed6574608f029c8e5906ae36c8381810e84148206ea2a22e11a48b35e5301' 
  AND token = 'j4C7pwO+80bLcnG1RiZ1f2IuRjVHZTFjsRVUdyNjAms=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}