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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f51b6fa563a0be645ea555ac192e5d00295012e57931b4bbe6b822801532a783' 
  AND token = '2VCeTpY3TM1nkQphlGINhFhK6pvdfLOgh2X+IW1pM5M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}