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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e28306716c127a59a059a9db2162e87d05d966de171019701a6a6e3e41ecc21' 
  AND token = 'j3YL2RrZUHqXUoDG9JYtphfzv8zDvRvxYnZAnWvI5Tw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}