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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40a727914297c8f1387d7778d0c7489cb572ce90fe55d975d0e773547b514046' 
  AND token = 'Ip1B5YrBxNkhIddX6pPbPEXCmhFnDdvRtoT+wlMpGxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}