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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '517277d3305e7b0c3cc5f5bca534308eed32936921f42f3c0ed37d60f8bbec00' 
  AND token = 'E9++f0i2XPVt6BfxZggLoiEHf6CFf5tMd5hRj63ZKgE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}