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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49df1ca99e8de5a87d70da133e46af7a361d112013aa428e1f7bc121e3ccdb36' 
  AND token = 'uEbks2bQnB+VTeK98v1CP/D9EU/BLXdJOhR86i4Jo0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}