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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '742572cb61112e6fa1b23e30883236bd119b98459019ee6ef3c1476a0be4dcb5' 
  AND token = 'u0mL4FrS0n1GjUxf/RHQIxCAjF3bSvs/LHzp2zpaPEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}