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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0eb5b0be738b978261adb7009c09daeee80ee8bbd02e979a5ee52e10f8c1c10a' 
  AND token = 'qdv9DBhQFRhzdKPbTGrWPeA0ly+q5INKbeuLuT2w3RM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}