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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41174e848ed9f36bf22d43ba5a19627b64b3f7c4c23cbf16fb76752e58181644' 
  AND token = '5yhTXSMfAWdaKK/LWe1NIG7V5mQYe3D7QV9Wk3VpEso=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}