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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43aeb681dcd2208ca3181fa74e417a4cfde04a8ae24d642e7b8e1cccd70646ca' 
  AND token = 'eQWfKMgQfl0k4YXh1u0GKLZHwCgBDHZGBMyCzqov6Gk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}