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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f45673bfb25bdf133d6da145dc61bf2deb5b8660bfdae176b09eed8ddda50b00' 
  AND token = 'JwV2ny09oIyqx0EpvyA+fmZQlz9mduzSus1NIQ1fyYE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}