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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a642efef90a937c83492945d9aa8270543fdc28fee2bc4c6f9bf787621867c70' 
  AND token = 'o/kqBiSiGNh8+OJUvuj4Xc99nN279OlXkNlzW8TBZTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}