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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e65405368ee54b426d7da04b7223f4027f49ebcb4f09b1463b3bb7f7e3c48508' 
  AND token = 'WXBDQnmtM9+KeTG+l0h0rPiyIjBBQ13eVysDDNloVWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}