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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc6859e16055be178d12450f5ef7015b34979738849ffabe06f77a2c6d22ad49' 
  AND token = 'mC2cIky0y4+xsqwC//Fp+0TLteTv3T8e75lWPSM95aU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}