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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9df436f1dcc006bea8f63c50292316e8cbc7152ff1ddf8bed4e6e5a367409528' 
  AND token = 'jqZAyoxKqX24MS2tq00qTU8JcPloiIOtJ5jPS1Ch3ZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}