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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e81dc8438626e2c57cf4d9d485fa26774dcd4e842d98d41d3eda6ca7110673' 
  AND token = 'E1pTDvgt1Q1vV9V95fWeABgHqKddfK6QpjBXPLsZSOM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}