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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f78e980f3b4bf1d1160b571311c390555d1bbb43e34239eb7e29befe9fdd4f59' 
  AND token = 'lPfiUnHm/HjvC8VSmoGrN6MD/kudfILOAYAW6lij5mQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}