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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e22043006e73b0794b6e1b30527f0a199cd297c55e44713656615dd9f237684' 
  AND token = '0R0o+wsRS3axK4Gt1EuWMDt77++jNwKsfEpNI0x7Xd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}