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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48f7e03d47284a89485de8f17fb2d5edcb645ba7df8d4e77e4bd09d1246c049c' 
  AND token = 'apgfAt/HIfkNzc4ybHbsdZHKO3jQp4fJjsxFk+Ht3Q0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}