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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b22a33a953829464054a5ec835dc91d304b339a0267e8c4707ca6ff663bf0519' 
  AND token = '04nbr9e9N5TwoZk6TmVq9aBHP6bBa+GRAMI2nufAajY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}