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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78545ea68061e683b3fd362c8816157d236041f1a4a67d6a2e3955bbe6f5174c' 
  AND token = 'ei3Pg4mUkPI1F3QWx67OOsovPUMXBFc2vnn8m+9DUFY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}