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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f648f81bac8f8a3bab3b217b35c1bc19f15b8f4b9b592532c1b19839c229616' 
  AND token = 'TD0880kVec+85bvjXx/HVabWe2iyjYzV8QurXDL3Xxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}