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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a7d75a53e643637a8177d726bf1a5d81c7965305d142519eebe84a01a39c7d6c' 
  AND token = 'uOKbasnsIAJ9nhLNAOYLq1KHTou3vRYtHGC8NAfIRiw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}