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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ef0cedfa0d845b7c75d2690a7f24e4711fc82b2521b845347637d59975b6a33' 
  AND token = '7tead0x+trafCPtX03KBRkmM8jaS9bTxBUumolx8f6A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}