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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cce62df25a818b3d6fae95008c03d3b9fdecf22c7fc6d19146840a4b16dd8afb' 
  AND token = 'o0W1Q59F4gnpHHK+ZZ08C6VgZiFiTEh4qhUO7b80VtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}