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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4b581017871b77e2b7e6e72a338efb865f74991bee7ac96f0d12f94d5fb5125' 
  AND token = 'dtYbbvaRZFCT+RORbD/345gPXa/X3sylPJLre55fS18=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}