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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f03be36f8675b0158327a6eb6b218d72db4c76bf5b7889e002d2d6bbfc8522a3' 
  AND token = 'S80u1JHkaRFKmhG3/e+0NimdrcXcP2m59Z1eWAHNsR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}