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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3ee20827a6693765da6398ffa4a2fe8109f9e7a1e7bb4e5ce9057943c335706' 
  AND token = 'v4xwQTVGJ03po8GosCf60sGUgIHCA9nwWb2XKxhTV4M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}