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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b00e7e64b3cce482a21896d123e9892e76ef09c4826bc38d6e8dd331c885f35' 
  AND token = 'sJ3JpLFhCoddUJhZVXOuJtzx0PgIWe5DXTrDHiTdvm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}