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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78412a72acbac772b3ae8852f26afb99eaa25392633f5899af360ced523e1d5e' 
  AND token = 'KB4IjeOcAFavaKAHGbf1fCr3JY3zODjLqKhK9JvjHAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}