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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f6c60564e94f7b022e98b8e94bd6643d5beac486fc3c1d9b17b88c462842003' 
  AND token = '6iR+VgXLG7VcTr3HeEjcZiN76uzSHq37oYRcT2JgIvw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}