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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '95f21cda5c47352c0275b9d0c5c980d415cdf2ef609dc64d60bc3dc013e481b6' 
  AND token = '+ZVFHUnyynYew90bIYxtWTXWPjYn9dmUbHUWnbdAoMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}