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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c483a0be8ace082f714b63907a2e43f734e036640c65008e4761b2c4174a86cd' 
  AND token = 'Avf+J3Utha9FHxshXSeGvBZCB1Q4rCNnn5oyP+UwdMY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}