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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa5e471177b40246af3810d1a717b19fde24ca721761335f45bb01beaff4f406' 
  AND token = 'UM9uRBGnFnWsxwgeaS39lrWnVGGPvSYUlGWATn3nPeM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}