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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66a1aac65d552e26000c3291dae72fc3122c0b19f96b22e49443763a21ecb220' 
  AND token = 'q7bfaOn2WA8NSlT0qsY42k+r4TkooV3+CRLNDofgXHg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}