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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d4659c7db456aebd2db7a0f0ffd5b00f8c6829a849d895035ec99fd745a2be1' 
  AND token = 'YkxWy571d7L8N+mv9YWGiW4QPEHmcbE3q8ZGh0CZXzY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}