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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52a2c630f8d11aef05321d85983e5eaf63ec2421a8725fda6a502927abd41ad6' 
  AND token = 'pRAQvpwcQls3A5b2qBhFXAnSw4HW+uwMSuTSNFOwi28=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}