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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9367af7357db044c16c84b00b0490e7eaf3011fc558174abc7fd9c0583498bbc' 
  AND token = 'Ds1HuSVTvqW9RWUrr1iyQpeKh0G5PlCBk8jFyQ0NpWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}