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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e453dfd56d444f9cf75ded0fcab212c353068757a235f220370c65e8c8db8cf9' 
  AND token = '+S9Y7HWGi7NvjtTnB0GE4BhduLhfFDfZQGEvh6hKTfk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}