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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de79742b0c06c527bd076507987c249a42d61881d81508900fd69b556e0ba072' 
  AND token = '456KGXlFiUOsCley/KLmpM14wafNWlK0PNVWtwSdiFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}