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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ec3558398c07e5d208563e1cf6b0b6bea714224a0dffe5c41887027425366de' 
  AND token = 'lTAWDSTkFeeUw0HFM7uXz5RvhIO20LDpHLDmFlNEqG0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}