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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80e1e289ac93128caf2635abe12894db0858d82248ee87a74f0776a68f44e1a6' 
  AND token = 'BRGKuzGK7MKM130+zWxL/rEl/Md2is7A7UGDeVPUjmE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}