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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c57afbea1a5c0f402a92f1cba0135b2bb39e4970508323ec31027a0d66fa3648' 
  AND token = 'aqw3V8QHI92ZTsWpKRHbNwyzJDcM5PH3zdEXvpYCeQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}