SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16c978e1e04a6be6aa44e2e6df63d2129ffd9978a91d7bec822bca8302b4c297' 
  AND token = 'iTaV6e+2oJZrRTZFk7d8zkAhSn2PGJgi+TkL8fBe8O0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}