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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3be60b6c12eb99cd4bcb33ac6516e95617868735cfbd417aeb22edf7dfde90e0' 
  AND token = '7EN9a4Hy7Z5OKO1Js+joaQffIpamNbBGwmhbs3PwkvQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}