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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ae15f34bac1de5e388a285d27186f6aa2a1b8bbc8e1e78200777547796914a' 
  AND token = 'zGDK57RQQa29T+9L+so09HEjGU2nrjYYsm8omZ5vwsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}